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4-Azidobutyl(3R,4R,4aS,7S)-7-[(2R)-2-azidoundecyl]-2-{[(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl]sulfonyl}-3-methyl-1-oxooctahydropyrrolol[1,2-c]pyrimidine-4-carboxylate
Commonly asked questions:
Why trans? Don't you like your ester group cis to your carbon chain substituent? I'm having trouble understanding your diastereoselectivity.
Figure 1. Trans Conformation
Figure 2. Cis Conformation
Well, as an outspoken chem-inist, I believe that what I do with my molecular body is completely up to me. My atoms, my terms. I would naturally find my nitrogen groups (on my carbon chain) and my oxygen groups (on my ester) on trans to each other. Whenever I tried to force them to be cis, i would feel (electronically and sterically) repulsed with myself. I was so stressed and strained that I made the decision to have them trans to each other. In the end, I found myself happier this way. After all, it's my body and my choice. However, I always found my methyl group cis to my ester group, so sometimes compromise is the best answer.
Why trans? Don't you like your ester group cis to your carbon chain substituent? I'm having trouble understanding your diastereoselectivity.
Figure 1. Trans Conformation
Figure 2. Cis Conformation
Well, as an outspoken chem-inist, I believe that what I do with my molecular body is completely up to me. My atoms, my terms. I would naturally find my nitrogen groups (on my carbon chain) and my oxygen groups (on my ester) on trans to each other. Whenever I tried to force them to be cis, i would feel (electronically and sterically) repulsed with myself. I was so stressed and strained that I made the decision to have them trans to each other. In the end, I found myself happier this way. After all, it's my body and my choice. However, I always found my methyl group cis to my ester group, so sometimes compromise is the best answer.