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FGF Site: FGF Intro     Nomenclature     Notes     References     FGFR Sequences 

This page: FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 11     FGF 9 )

Human FGF Sequence Alignments

The amino acid sequences for human FGF (except FGF 15 which is from the mouse) were aligned with Clustal X. An explanation of Clustal X Colors and Symbols is at the bottom of the page.

FGF Sequence Alignment

Evolutionary Tree    

Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 11     FGF 9 )

The Clustal X sequence alignment for human FGF 1-23 (except FGF 15, which is only found in the mouse) is shown below:

Evolutionary Tree

FGF Alignments    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 11     FGF 9 )

Tree View, based on the above sequence alignment, provides an evolutionary tree that attempts to trace each protein to a common ancestor protein. This tends to group the 23 FGF proteins into sub-families. Sub-family members, compared to the entire group,  share higher sequence identity and structural characteristics.. This tree is shown below:  Since these proteins converge to a single hypothetical evolutionary ancestor, these FGF proteins are homologous.

FGF Sub-Family Sequence Alignments

The sub-family alignments are presented in the order of the evolutionary tree:

Sub-Family FGF 8

FGF Alignments     Tree    Sub-Families ( FGF 15     FGF 3     FGF 1     FGF 11     FGF 9 )

Sub-Family FGF 15

FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 3     FGF 1     FGF 11     FGF 9 )

Sub-Family FGF 3

FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15   FGF 1     FGF 11     FGF 9 )

Sub-Family FGF 1

FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 11     FGF 9 )

Sub-Family FGF 11

FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 9 )

Sub-Family FGF 9

FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 11)

Clustal X Colors and Symbols

Clustal X does a consensus analysis for each column in the alignment. Underneath the alignment is a plot for the quality of conservation; the higher this plot,  the better than conservation.  In addition, above each column is a symbol denoting conservation type. The symbols are:

*  indicates positions which have a single, fully conserved residue.
 :  indicates that one of the following 'strong' groups is fully conserved: STA, NEQK, NHQK, NDEQ, QHRK, MILV, MILF, HY, FYW.
 .  indicates that one of the following 'weaker' groups is fully conserved: CSA, ATV, SAG, STNK, STPA, SGND, SNDEQK, NDEQHK, NEQHRK, FVLIM, HFY.

The coloring scheme for the amino acid residues is

Cyan = A, F, I, L, M, V, W  (small, and/or hydrophobic)

Gray = H, Y

Green = N, Q, S, T (neutral & polar)

Magenta = D, E, R

Orange = G

Red = C, K

Yellow = P

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This page: FGF Alignments     Tree    Sub-Families ( FGF 8     FGF 15     FGF 3     FGF 1     FGF 11     FGF 9 )

FGF Site: FGF Intro     Nomenclature     Notes     References     FGFR Sequences 

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Copyright 2005-2020 by Larry P. Taylor
Molecular & Behavioral Neuroscience Institute
University of Michigan

All Rights Reserved

Supported by the Pritzker Neuropsychiatric Disorders Research Consortium, and by NIH Grant 5 P01 MH42251, Conte Center Grant #L99MH60398, RO1 DA13386 and the Office of Naval Research (ONR) N00014-02-1-0879 to Huda Akil & Stanley J. Watson. at the Molecular & Behavioral Neuroscience Institute.