Chapter 9: Reaction Mechanisms, Pathways, Bioreactions and Bioreactors


Sketch Competitive Inhibition on a Lineweaver-Burk Plot


\( \frac{1}{-r_S} = \frac{K_M \left( 1 + \frac{(I)}{K_I} \right) + (S)}{V_{\max} (S)} = \frac{1}{V_{\max}} + \frac{K_M \left( 1 + \frac{(I)}{K_I} \right)}{V_{\max} (S)} \)


Increase (I) concentration increase slope intercept remains unchanged.

Lineweaver-Burk plot for competitive inhibition, showing inverse reaction rate (1/-rs) versus inverse substrate concentration (1/S). The plot includes a 'No Inhibition' line and steeper lines for increasing inhibitor (I) concentrations, converging at the same y-intercept.

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