| family |
name |
apoptosis |
NF-kB
|
AP1 |
KO |
gene |
Structure |
3D |
locus |
TFs |
regulators |
target |
memo |
IL1 superfamily
|
IL-1a (human
, mouse
, rat
, house
, dog,
sheep,
bovine,
pig,
rabbit) |
inhibit/enhance |
activate
|
activate |
L |
1 |
IL1 |
1 |
2q14 |
AIRE
|
IL1,
IL8,
IL18,
TNFa,
RANKL,
CD8/28,
CD43,
IFNg,
GCSF,
M-CSF,
IL10,
C3b/C4b,
XNA,
PMA,
serum,
EGF,
LPS,
BLP
,MDP,
b-glucan, flagellin,
CpG,
Bm,
Hp, Hf, Pg, St,
Ye,
MVA,
tax,
AmB,
Erks,
RA,
cantharidin |
list |
|
|
IL-1b (human,
mouse,
rat,
house, sheep,
bovine,
rabbit,
dog,
cat,
pig,
chicken,
frog,
r.trout
1,2,
carp
1, 2) |
inhibit/enhance/(-) |
activate
|
activate |
L |
1 |
(TM)/IL1 |
1 |
2q14 |
NF-kB,
NF-IL6,
PU.1,
Sp1,
HSF1,
IRF2,
Gfi1,
EWS/FLI-1,
PPARg,
PDX1,
twist2 |
LPS,
BLP,
MDP,
b-glucan, hsp65,
Bm,
Cp,
Ct,
Ec,
Ft,
Ld,
Lm,
Hi, Ma,
Mt,
Sa,
St,
Tg,
flagellin,
BCG,
dsRNA,
CpG,
EBV,
HHV8,
Tax,
CMV
IE2, VLP,
IL1,
IL5,
IL16,
IL18,
IFNa,
IFNb,
IFNg,
FVIIa,
CD8/28,
XNA,
PMA/Io,
CD43,
MHC,
TNFa,
Fas,
RANKL,
CD40,
Wnt3a,
C3b/C4b,
bradykinin,C5a,
SCF,
histamine,
CRH,
DEX,
D3,
PGE2,
UVB,
HSF1,
RANTES,
CXCL5,
IL2,
IL10,
AgII,
TGFb1,
PAF,
lactoferrin,
Rac2,
FADD,
JNKs,
AmB,
mechanically, |
List,
SAA, |
casp 1 |
|
IL-1Ra (human,mouse) |
inhibit,(-)
|
inhibit
|
inhibit |
L |
1 |
IL1 |
1,
R |
2q14.2 |
NF-kB,
STAT3,
STAT6,
PU.1 |
IL-4,
IL10,
IL13,
CD3/28/TCR,
XNA,
TNFa,
GM-CSF,
SCFPTH,
LPS,
PGN,
MDP,
Sp, MVA,
hypoxia,
Raf-1,
p38,
HCMV
IE1, leptin,
BMP2,
BMPs;
ATP/P2X7
|
INAP |
, TNFa, |
|
IL-18, IGIF(human,
mouse,
rat,
Ap,
chick) |
enhance
|
activate
|
activate |
L |
1 |
(TM)/IL1 |
|
11q22.2-q22.3 |
AP-1,
Elf-1,
IRF1,
ICSBP,
Bcl6 |
IFNa,
IFNg,
ACTH,
TSH,
TRH,
PMA,
LPS,
Cp, Hf, Pg, Sd,
VLP,
estrogen,
androgen,
RON/MSP,
TRIF,
M-CSF,
IL10
|
IFNg,
FasL |
casp 1 |
|
FIL1d, IL1RP3, IL1HY1, IL1F5 (human) |
|
|
|
|
1 |
IL1 |
|
2q14.2 |
|
|
|
|
|
FIL1e, IL1e, IL1F6 (human) |
|
induce
|
induce |
|
1 |
IL1 |
|
2q12-q14.1 |
|
|
|
|
|
FIL1zeta(human),
IL1H(L,S),
IL-1X, IL1F7 |
|
|
|
|
1 |
IL1 |
|
2q12-q14.1 |
|
PMA |
|
binds IL18R,
IL18BP |
|
FIL1eta, FIL1, IL1F8 (human) |
|
induce
|
induce |
|
1 |
IL1 |
|
2q12-q14.1 |
|
|
|
|
|
IL-1H1, IL1RP2, IL1F9 (human) |
|
induce
|
induce |
|
|
IL1 |
|
2q12.1 |
|
ALA
|
|
|
|
IL1F10 (human) |
|
|
|
|
|
IL1 |
|
2q14.1 |
|
|
|
|
|
FGF1/acidic FGF(human,
mouse,
pig) |
inhibit
|
activate
|
|
1 |
|
IL1 |
L |
5q31 |
IRF3 |
|
IL2,
actins,
FR17,
estrogen
|
|
|
FGF2/basic FGF(human,
mouse,
sheep,
frog) |
inhibit
|
|
|
L |
|
IL1, FGF family |
L |
4q26-q27 |
E2F1,
p53,
AP1,
Egr1,
HOXB7 |
OSM,
IL1,
TNFa,
PMA,
serum,
hypoxia,
AgII,
Ye,
heat,
density,
PTH,
FSH,
cAMP,
NAcR,
I3C,
ribavirin, |
list,
actins,
NGFR,
a1, osteocalcin,
elastin,
LDL-R,
D-cyclin,
PGHS-2,
FGFR1,
integrin,
IGF-IR,
b-amyloid,
i.collagenase, |
anti-BMP4 function |
|
FGF3/INT2/(human,
mouse,
frog,
zebrafish) |
|
|
|
L |
|
FGF family |
|
11q13 |
|
RA,
cAMP |
|
inner ear, skeletal |
|
FGF4/HSTF1/HST/KFGF(human,
mouse,
bovine,
chicken,
frog II) |
inhibit
|
|
|
L |
|
FGF family |
|
11q13 |
NF-Y,
Sp1
|
progesterone,
b-catenin |
FGFRs,
prolactin |
inner cell mass, anti-BMP4 function |
|
FGF5 (human,
mouse) |
|
|
|
L |
|
FGF family |
|
4q21 |
|
SCF,
FSH |
|
hair growth |
|
FGF6/HST2(human) |
|
|
|
1 |
|
FGF family |
|
12p13 |
|
MDP,
cisplatin |
|
|
|
FGF7/KGF(human,
mouse,
sheep,
dog) |
inhibit
|
|
|
L |
|
FGF family |
1 |
15q15-q21.1 |
|
estrogen,
SCF,
Subst.P,
LPS,
Pg
|
|
|
|
FGF8/AIGF(human) |
regulate
|
|
|
L |
|
FGF family |
|
10q24 |
|
androgen |
|
limb formation, gastrulation |
|
FGF9(human,
mouse,
rat,
frog) |
inhibit
|
|
|
L |
|
FGF family |
|
13q11-q12 |
HOX11
|
MDP,
Subst.P,
LPS,
MVA |
|
lung branch, sex |
|
FGF10 (human,
mouse,
rat) |
inhibit
|
|
induce
|
L |
|
FGF family |
|
5p13-p12 |
Tbx4
|
TGFb
|
|
multiorgan |
|
FGF11, FHF3(human,
mouse) |
|
|
|
|
|
FGF family |
|
17p13.1 |
|
|
|
|
|
FGF12, FHF1(human) |
|
|
|
|
|
FGF family |
|
3q28 |
CREB |
|
|
|
|
FGF12B(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
3 |
|
|
|
|
|
FGF13 (human,
mouse) |
|
|
|
|
|
FGF family |
|
Xq26.3 |
Brn3a
|
|
|
|
|
FGF14/FHF4(human,
mouse) |
|
|
|
1 |
|
FGF family |
|
13q34 |
|
LPS |
|
|
|
FGF15 (mouse,
rat) |
|
|
|
|
|
FGF family |
|
|
|
Subst.P |
|
|
|
FGF16(human,
mouse) |
|
|
|
|
|
FGF family |
|
8p21.3 |
|
|
|
|
|
FGF17(human,
mouse) |
|
|
|
1 |
|
FGF family |
|
8p21 |
|
ARNT2
|
|
cerebella |
|
FGF18(human,
mouse,
rat) |
|
|
|
L |
|
FGF family |
|
5q34 |
|
|
|
|
|
FGF19(human,
mouse) |
|
|
|
|
|
FGF family |
|
11q13.1 |
|
ALA
|
|
|
|
FGF20(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
8p22-p21.3 |
|
|
|
|
|
FGF21(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
19q13.1-qter |
|
|
|
|
|
FGF22(human,
mouse) |
|
|
|
|
|
FGF family |
|
19p13.3 |
|
|
|
|
|
FGF23(human,
mouse,
rat) |
|
|
|
1 |
|
FGF family |
|
12p13.3 |
|
|
|
|
beta c
|
IL-3 (human,
mouse,
rat,
bovine,
sheep) |
inhibit/(-)
|
initiate
|
|
L |
1 |
|
|
5q31.1 |
NF-kB,
Oct1,
E4BP4,
NF-AT,
YY1,
ASRF, Egr2,
Egr3, DB1 |
CCR3,
JNK,
Ma, b-glucan |
(activates Jak2,Stat5) |
T |
| GM-CSF, CSF2 (human,
mouse,
rat,
sheep,
pig,
bovine,
horse,
dog,
cat,
) |
inhibit
|
|
|
L |
|
|
1 |
5q31.1 |
NF-kB,
AP1,
Elf1,
AML1,
Ets1,
Ets2,
EWS/FLI-1,
NF-ATp,
PEBP2,
PU.1,
C/EBPa,
HMG-I,
D3R, |
IL1,
IL2,
IL7,
TNFa,
TWEAK,
GMF,
TCR/CD3/28,
PMA,
FceRI,
CD43,
TREM1,
LPS,
MDP,
CpG,
CSD,
UVB,
hypoxia,
tax,
FK506,
rapamycin,
lactoferrin,
IFNa,
IFNg,
CsA,
glucocorticoids, |
targets |
|
gamma c
|
IL-2, TCGF (human,
mouse,
rat,
cat,
dog,
sheep,
bovine,
chicken) |
inhibit/(induce)/(-)
|
activate,*
|
(-) |
L |
1 |
IL2 |
1 |
4q26-q27 |
NF-kB,
AP1,
CREM,
AP3,
ILF1,
c-Myc,
OCT1, NF-AT,
NF-IL6,
IRF4,
PPARg,
Elf1,
PU.1,
YY1,
(review) |
TNFa, IL1,
IL4,
IL7,
IL12,
IL15,
IL17,
IL18,
LFA-1,
TCR/CD3/28/PMA,
CD80,
CD86,
PD-1,
B7H4,
Notch,
TRH,
4-1BB,
TGFb1,
FGF1,
MCP1,
HRF,
Sd,
Sm, Mt,
DEX,
PGE2,
cAMP,
oxLDLs,
FK506,/CsA,
NAC,
Monochloramine,
cannabinoid,
Tax,
CD2,
CD69,
CD101,
EphB6,
ATP,
CB1,
PKCtheta,
Tat,
Tpl-2,
Akt,
Itk,
TRAF5,
IRAK,
JNK,
MEKK2,
Ras,
GILZ,
HuR,
Pim-1,
SSA,
Shc |
(activates Jak1/3,Stat1/3/5)
targets,
Bcl2,NF-kB,
M-CSF,
c-fos |
|
| IL-15 (human,
mouse,
rat,
dog,
sheep,
bovine,
pig,
chicken) |
inhibit,
(-,
NK) |
|
|
L |
1 |
IL2 |
|
4q31 |
NF-kB,
AIRE |
tax,
IL1,
IL16,
IFNs,
GM-CSF,
PD1,
dsRNA,
B-DNA,
LPS,
sBLP,
MVA,
RON/MSP,
ribavirin,
TRIF,
estrogen,
androgen
|
(activates Jak1/3,Stat3/5)
targets,
IL8, Bcl-xL |
|
| IL-21 (human,
mouse) |
inhibit/
induce
|
|
|
|
|
IL2 |
|
4q26-q27 |
|
|
(activates Jak1/3,Stat1/3/5) |
|
IL4 (Th2)
|
IL-4/BSF1 (human,
mouse,
rat, cat, dog,
sheep,
bovine) |
inhibit/enhance
|
inhibit
|
|
L |
1 |
IL4 |
1 |
5q31.1 |
NF-AT,
NFATx,
c-Maf,
NIP45,
NF-Y,
HMG-I,
STAT6,
GATA3,
IRF1,
IRF2,
IRF4,
CIITA,
AP1, JunB,
AIRE,
NF-kB,
C/EBPgamma |
IL25,
IL16,
CD40,
TCR,
PMA,
CD28,
CD86,
B7H2,
IFNg,
Jak1,
Vav,
PKCtheta,
cAMP,
Nef,
EBV, MDP,
Sm, VLP,
CsA,
D3,
androgen |
(activates Jak1/3,Stat6)
targets,
Bcl2,
IL6,
|
B act. |
IL-13 (human,
mouse,
rat,
bovine) |
inhibit
|
inhibit
|
inhibit |
L |
1 |
IL4 |
1 |
5q31 |
GATA3,
IRF4,
c-Myc,
NF-ATs
|
IL25,
IL12,
CD3/28,
PMA,
Hi, Sm, nicotine,
UVB,
CNAIP,
TSH,
TGFb,
HRF,
TIMP1 |
(activates Jak1/2/3/Tyk2,Stat6)
targets
|
|
| IL-5, EDF (human,
mouse,
rat,
cat,
bovine) |
inhibit/enhance
|
|
|
L |
1 |
IL4 |
1 |
5q31.1 |
GATA3,
AP1,
NF-AT,
NFATx,
Bcl6,
ARNT2
|
IL25,
RANKL,
SCF,
CD3/28/TCR,
CD86,
IL10,
cAMP,
PKA,
PMA,
flu
v, CsA,
OX-CA |
(activates Jak2,Stat5)
targets |
eosinophil trafficking |
gp130
|
IL-6 (human,
mouse,
rat,
bovine,
house,
sheep,
chicken,
fugu)
|
inhibit/induce
|
|
(-) |
L |
1 |
IL6 |
1 |
7p21 |
NF-kB,
AP1,
JunB,
NF-IL6,
CREB,
EGR1,
C/EBPg, C/EBPd,
IRF2,
CBF1,
STAT3,
p53,
PDX1,
HSF1
|
LIF,
Fas/FasL,
TNF,
TRAIL,
4-1BB,
CD40,
IL1,
IL4,
IL10,
IL16,
IL17,
IL17D,
IL18,
IL19,
IL26,
GM-CSF,
IFNa,
OsM,
AgII,
CD8/CD28,
XNA,
IgE,
CD43,
PMA,
ML-1,
histamine,
LTB4,
Subst.P,
ET-1,
SST,
bradykinin,
SHIP,
PTH,
TRH,
PTHrP,
Thrombin,
IGF2,
C5a,
lactoferrin,
E1A,
HBx,
radiation,
LPS,
MDP,
BLP,
CpG,
b-glucan, dsRNA,
PGN,
R848,
MALP2,
TBhsp70,
BCGhsp65,
Bm,
Ct,
Ec,
Hp,
Ma,
Mt,
Pg, St,
Sa,
Lm,
Mt,
Tg,
Ye,
LTA,
RSV,
AdV,
HHV8,
MVA,
VLP, hypoxia,
heat
shock, UVB,
TGFb,
FLT3L,
microcrystals,
vFLIP,
CD101,
cAMP,
PGE2, NAC,
MAIL,
DEX,
D3,
IKKs,
MAL,
TRIF,
RICK,
Erk1/2,
M2,
p38,
JNKs,
p21,
camptothecin |
(activates Jak1/2,Stat1/3)
Bcl2,
Bax, Bcl-xL, PAF,
SAA |
|
| G-CSF, CSF3 (human,
mouse,
cat,
bovine,
pig,
sheep),
MGF(chicken) |
inhibit
|
|
activate |
L |
1 |
IL6 |
|
17q11.2-q12 |
NF-kB |
IL1,
IL17,
LPS,
MDP,
BLP,
CpG,
Ec,
St,
Sa,
Lm,
Mt,
Pg, BCG,
VLP,
IL17F,
Thrombin,
Subst.P,
calcineurin,
tax,
IL10 |
targets,
A1 |
|
| oncostatin M, OSM (human) |
inhibit
|
|
|
|
|
LIF subfamily |
|
22q12.2 |
STAT5 |
IL2,
IL3,
EPO,
Fas,
PMA,
Hp,
camptothecin |
(activates Jak1/2,Tyk2, Stat1/3) |
|
| LIF (human,mouse,
rat,
pig,
sheep,
dog,
bovine) |
enhance/inhibit
|
|
|
L |
|
LIF subfamily |
1 |
22q12.2 |
NF-kB |
TNFa,
IL1,
IL2,
IL7,
IL12,
IL15,
PMA,
CD3/28,
TGFb,
LPS,
Ct,
Lm,
Ma,
St,
Sd,
Ye,
HHV8,
irrad,
UVB,
FVIIa,
CsA,
IKKs |
(activates Jak1/2,Tyk2, Stat1/3)
targets |
|
IL-11, AGIF(human,
mouse,
rat,
fugu)
|
inhibit
|
inhibit
|
|
|
1 |
IL6 subfamily |
|
19q13.3-q13.4 |
AP-1,
NF-kB,
EWS/FLI-1 |
TGFb,
IL1,
TNFa,
insulin,
DEX,
heparin,
Mt,
M-CSF,
SCF,
TPA,
IKKs |
(activates Jak1,Stat1/3)
|
|
IL-12 (hIL-30uman alpha/p35,
beta/p40)
|
inhibit/(-)/promote
|
induce
|
|
L |
a |
a(IL6), |
L |
IL12A (3p12-q13.2) |
NF-kB,
AP1,
AIRE,
Ets2,
C/EBP,
EKLF,
IRF1,
IRF2,IRF8,
Sp1,
STAT4,
STAT6 |
IFNg,
IFNb,
IFNk,
CD40,
TNFa,
RANK,
vitamin
D3, IL4,
IL6,
IL10,
IL13,
MCP1,
VIP,
LPS,
b-glucan, Hp, Sm, (Tg),
LeIF,
CD154,
B7-DC,
bradykinin,
IL4R1,
C1q,
MAST205,
Vpr,
TRIF,
curcumin,
S-27609,
parthenolide |
(activates Jak2,Tyk2, Stat4)
targets
|
T, NK>INFg byPBMC |
|
L |
b |
b(FN3) |
|
IL12B (5q31.1-q33.1) |
NF-kB,
IRF1,
ICSBP,
C/EBP,
STAT3,
NFAT,
c-Maf |
IL1,
IL4,
IL10,
IFNb,
IFNg,
RON/MSP,
LPS,
CpG,
Ba,
Ec,
Re, Pg, St,
Sa,
Sm, Lm,
Mt,
TBhsp70,
VapA,
HIV1,
HCV
core, MgHV68, BCG,
CD154,
DEX,
apoptotic
cells |
|
| IL-23
p19,
SGRF(human,
mouse,
pig) |
(inhibit)
|
|
|
L |
|
IL6
+IL12b(see above) |
|
12q13.13 |
|
IFNg, LPS,
TLR4,
TRIF |
(activates Stat4) |
|
IL-31
(human, mouse)
|
|
|
|
|
1
|
IL6
|
|
12
|
|
|
|
|
| IL-27, IL-30, p28 (human) |
|
|
|
|
|
IL6 |
|
16p11 |
|
|
(activates Jak1/2,Tyk2, Stat1/3/4/5)
t-Bet |
|
| EBI3, IL-30 (human) |
|
|
|
|
|
FN3 |
|
19p13.3 |
|
EBV,
IFNb,
TIMP1
|
|
|
| CNTF (human,
mouse,
rat,
rabbit,
pig,
chick) |
inhibit
|
|
|
L |
|
IL6 |
1 |
11q12.2 |
|
IL1,
IL6,
RA,
levobetaxolol |
|
|
gamma c
|
IL-7 (human,
mouse,
rat,
bovine,
sheep) |
inhibit/(-)/induce
|
activate
|
activate |
L |
1 |
|
|
8q12-q13 |
p53,
p73 |
IFNg,
LPS,
PD1,UV,
Hp,
Pg, MVA,
VLP,
TIMP1 |
(activates Jak1/3,Stat3/5)
targets,
IL2,
Bcl2 |
|
|
IL-9/p40(human,
mouse) |
inhibit
|
inhibit
|
|
L |
1 |
secreted |
|
5q31.1 |
NF-kB,
AP-1, |
CD3/CD28,
Ma, b-glucan, AIRE
|
(activates Jak1/3,Stat1/3/5)
Bcl3 |
support h-T(2-/4-) |
| CXCL |
IL-8, SCYB8, NAP1, GCP1(human) |
inhibit/(-)
|
|
|
|
1 |
|
1 |
4q12-q13 |
NF-kB,
AP-1,
NF-IL6,
TCF4,
TEF1,
CREB,
CRE-BPa,
EWS/FLI-1,
MEF,
XBP1,
NR2F2,
C/EBPs,
p300,
TORC |
TNFa,
IL1,
Fas/FasL,
TRAIL,
LTb,
TWEAK,
4-1BB,
CD40L,
BCR,
XNA,
CD8/28,
PMA,
CD43,
IL5,
IL12,
IL13,
IL17,
IL17D,
IL17F,
IL18,
IL26,
GM-CSF,
GCSF,
VEGF,
IFNg,
neurotensin,
VIP,
histamine,
LTB4,
fumagillin,
gastrin,
lactoferrin,
Ox-
stress, irrad,
UV,
hypoxia,
, NO,
stretch,
FVIIa,
LPS,
BLP,
MDP,
KF1B,
CpG,
LTA,
b-glucan, Bm,
Cp,
Ec,
Hp,
Ld,
Lm,
Ma,
Mt,
Sa,
Sd,
Sp, St,
Sp,Tg,
Ye,
TBhsp70,
BCGhsp65,
flagellin,
dsRNA,
BCG,
EBV,
HHV8,
MVA,
EV71,
SARS,
RANTES,
b-catenin,
estragen,
DEX,
RA,
doxorubicin,
glucose,
OmpA-likeCannabinoid,
CsA,
MEK1,
MLK3,
Erk1/2,
DRR1,
p38,
RICK,
PKCd,
PKK,
ZIPK,
TNFR1,
TRAF6,
cFLIP,ACT1,
CDC42,
Rac1,
p114,
p115,
C16orf15,
Tid1,
fibonectin,
HuR,
PGE2,
Gln,
Ni3S2,
AmB |
TNFa,
Raf |
chemokine |
|
For other chemokines, see IL8
family
|
|
|
|
IL-10
|
IL-10, CSIF (human,
mouse,
rat,
cat,
dog,
bovine,
sheep,
pig,
house) |
induce/inhibit
|
potentiate/inhibit |
induce |
L |
m |
IL10 homodimer |
1 |
1q31-q32 |
NF-kB,
AP1,
STAT3,
GATA-3,
C/EBPs,
IRF1,
IRF4,
c-Maf,
SMAD3,
Gfi1 |
TNFa,
IL1,
BAFF,
CD46,
IL2,
CD3,
B7H2,
PMA, TREM1,
IL1b/IFNg,
IFNa,
IFNk,
IL10,
FLT3L,
lactoferrin,
CIS3,
Subst.P,
LPS,
BLP,
, b-glucan, Ct,
Ma,
Py,
Sm, HCV
NS3, VLP,
LeIF,
hsp90b,
TNFR2,
MDP/Nod2,
CsA,
cAMP,
apoptotic
cells |
(activates Jak1,Tyk2, Stat3)
targets,
IFNg,
IL2, IL3, IL12,
GM-CSF, TNFa |
enhance Th2 |
| IL-19, MDA1, NG.1, ZMDA1, IL-10C (human,
mouse
19A, 19B,
rat) |
induce
|
|
|
|
|
IL10 |
1 |
1q32 |
|
LPS |
STAT targets |
|
| IL-20 (human,mouse) |
|
|
|
|
|
IL10 |
|
1q32
|
|
D3,
LPS
|
STAT3 targets |
|
| IL-22/IL-TIF(human) |
|
|
|
|
1 |
IL10 |
|
12q15 |
|
IL-9,
LPS |
(activates Stat1/3/5)
STAT,
SAA,
a1-1-antichymotrypsin, Hpa1 |
|
| IL-24, MDA-7, ST16, mob-5, C49a (human,
mouse,
rat) |
induce
|
induce
|
induce
|
|
|
IL10 |
|
1q32 |
AP-1,
C/EBP |
RET
|
STAT
targets |
|
| IL-26, AK155, ML-1 (human) |
|
|
|
|
|
IL10 |
|
12q15 |
|
|
IL6,
IL8 |
|
| IL-28A
(human) |
|
|
|
|
|
IL10 |
|
19q13.13 |
|
IFNa,
viruses
|
(activates Stat2/3) |
|
| IL-28B
(human) |
|
|
|
|
|
IL10 |
|
19q13.13 |
|
|
(activates Stat2/3) |
|
| IL-29
(human) |
|
|
|
|
|
IL10 |
|
19q13.13 |
|
IFNa,
viruses
|
(activates Stat2/3) |
|
| BCRF1(EBV),
vIL-10(CMV, HPV,
YDV) |
|
|
|
|
1 |
IL10 homodimer |
w/sIL10R1 |
|
|
|
inhibit IFNg ind. |
|
| IFN alpha (1: human,
zebrafish) |
inhibit/
sensitize |
activate |
|
|
|
IL10 |
|
9p22 |
E2F1,
ARNT2
|
IL25,
IFNa,
LPS,
MDP(-),
dsRNA,
viruses, VLP,
hsp65,
BDCA2,
TLR7,
RA,
D3,
androgen |
(activates Jak1,Tyk2, Stat1/2)
targets |
|
| IFN beta (2: human) |
promote
|
|
|
L |
|
IL10 |
|
9p21 |
AP1,
NF-kB |
TRAIL,
RANKL,
IL1,
IL10,
IFNa,
BDCA2,
LPS,
Lm,
TGFb, dsRNA,
viruses, VLP,
NO,
estrogen,
hypoxia,
IKKi,
TBK1,
TRIF,
ribavirin |
(activates Jak1,Tyk2, Stat1/2)
targets |
|
| IFN kappa (human) |
|
|
|
|
|
IL10 |
|
9p21.2 |
|
dsRNA,
IFNa,
IFNb |
|
|
| IFNg |
IFN gamma (human,
mouse,
rat,
rabbit,
dog,
horse,
bovine,
sheep,chicken) |
induce
|
|
|
L |
|
|
|
12q14 |
IRFs, AP1,
STAT3,
STAT4,
t-Bet,
Hlx,
GATA-3,
IRF2,
NFATx |
virus, VLPs,
IL1,
IL2,
IL4,
IL10,
IL12,
IL15,
IL18(-),
IL21,
IL27,
TGFb,
IFNa,
IFNb,
TGFb,
LPS,
dsRNA,
Cp, Hp, Mt,
Pf,
Py,
BCG,
MgHV68, VLP,
CD40,
TCR/CD3/CD28,
B7s,
LFA3,
TNF,
Fas,
TL1A,
MHC,
Ly49D,
CD69,
CD82,
CD84,
CD244,
jagged-1,
Notch,
TSH,
FLT3L,
PF4,
RON/MSP,
KIR2DL4, hypoxia,
ATP,
A2A,
Akt,
Ly49,
Txk,
Tyk2,
SOCS1, flu
v, morphine,
HIVp17 |
(activates
Jak1/2, Stat1/5)
targets |
Th1 |
| Eph |
IL-14 (human) |
|
|
|
|
1 |
Signal/Eph/TM |
|
9 |
|
|
|
|
| IL16 |
IL-16/LCF (human,
mouse) |
inhibit
|
|
|
|
|
|
|
15q26.3 |
GABPalpha,
p300 |
TNFa,
IL1,
IL4,
IFNa,
caspase-3 |
IL-2,
CtT,
CsA/FK506,
FceRI, BRCA1, |
|
IL17
|
IL-17 (human,
mouse) |
|
activate
|
activate |
L |
? |
cystine
knot |
1 |
2q31 |
NF-ATs
|
IL1,
IL6,
IL8,
IL15,
OX40,
LPS,
Sd,
Hp,
TRAF6,
TLR4,
IL23 |
IL1b,
TNFa, IL23,
GCSF,
ICAM1,
IkBa,
RANTES,
C3,
FB, CD3&IL2 |
|
| IL-17B/CX1/NERF
(human,
mouse) |
|
|
|
|
|
cystine knot |
|
5q32-34 |
|
|
TNFa,
IL1b |
|
| IL-17C/CX2
(human) |
|
|
|
|
|
cystine knot |
|
16q24 |
|
|
TNFa,
IL1b |
|
| IL-17D, IL27 (human) |
|
|
|
|
|
|
|
13q12.11 |
|
|
|
|
| IL-25, IL-17E(human) |
|
activate
|
|
|
1 |
cystine knot |
|
14q11.2 |
|
|
IL8,
IL6,
IL4,
IL5, IL13, IFNa, TARC, Eotaxin, LIX |
EVI27/IL-17BR |
| IL-17F/ML-1(human) |
|
|
|
|
1 |
cystine knot |
1 |
6p12.1-21.1 |
|
|
IL8,
GCSF, IL23,
IL6, IFNg, |
|
| EPO |
Epo, erythropoietin(human,
mouse,
rat,
cat,
dog,
bovine,
sheep) |
inhibit
|
activate
|
activate |
|
1,2 |
EPO |
L |
7q21 |
HIF1,
HNF4,
GATA1,
GATA2,
Sart-1,EAR3,
NF-kB |
hypoxia,
RA,
TNFa,
IL1,
IL5,
AgII,
estrogen |
Bcl-xL,
GATA-2,
Hrk |
|
|
Tpo, thrombopoietin, MKCSF, MGDF (human,
mouse,rat,
) |
inhibit
|
|
activate |
1 |
1 |
EPO |
|
3q26.3-q27 |
E4TF1 |
estrogen,
Subst.P,
LPS |
|
|
|
SF20/IL25=IL27(human,
mouse) |
|
|
|
|
|
|
|
19p13.3 |
|
|
|
|
| M-CSF |
M-CSF, CSF1, MCSF (human) |
mediate
|
|
|
op |
|
|
|
1p21-p13 |
|
IL2,
IL4,
IL7,
IL15,
PMA,
IGF1,
UVB,
LPS,
TNF,
RA,
VLP
|
targets |
|
| leptin |
leptin, Ob (human) |
induce/
inhibit
|
|
|
ob |
|
|
|
7q31.3 |
PPARg, C/EBPa, HIF1,
SREBP1 |
hypoxia,
insulin,
glucose |
|
diabetes II |
| Somatotropin |
growth hormone, GH1 (human) |
inhibit
|
|
|
|
|
|
|
17q24.2 |
|
|
|
|
|
prolactin, PRL (human) |
induce/
inhibit
|
|
|
|
|
|
|
6p22.2-p21.3 |
|
|
|
|
| HRF |
HRF, TPT1 (human,
mouse, zebrafish,tabacco,
yeast) |
|
|
|
|
|
|
|
13q12-q14 |
|
|
IL2,
IL13 |
|
Copyright
by Naohiro
Inohara,
Department
of Pathology, University of of Michigan
Medical School