Publications � Transcription Factor Interactions
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Ramirez-Carrozzi, VR and Kerppola, TK: gelFRET analysis
of nucleoprotein complexes.� Methods
25:� 2001
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Ramirez-Carrozzi, V. R. and Kerppola, T. K.� Control
of the orientation of Fos-Jun binding and the transcriptional cooperativity of
Fos-Jun�NFAT1 complexes.� J.
Biol. Chem. 276:21797-21808,� 2001. �[Abstract] [Full
text] [PDF]
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Chinenov, Y and Kerppola, TK: Close encounters of many
kinds: Fos-Jun interactions that mediate transcription regulatory specificity.� Oncogene 20:2438-2452,� 2001.�
[Abstract] [Full
text] [PDF]
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Ramirez-Carrozzi, VR and Kerppola, TK: Dynamics of
Fos-Jun-NFAT1 complexes.� Proc. Natl.
Acad. Sci. U.S.A. 98:4893-4898, 2001.� [Abstract] [Full
text] [PDF]
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Dlakic M, Grinberg, AV, Leonard, DA and Kerppola, TK:
DNA sequence-dependent folding determines the divergence in binding
specificities between Maf and other bZIP proteins.� EMBO Journal 20: 828‑840, 2001.� [Abstract] [Full text] [PDF]
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Ramirez-Carrozzi, VR and Kerppola, TK: Long-range
electrostatic interactions influence the orientation of Fos-Jun binding at AP-1
sites.� J. Mol. Biol. 305: 411-427,
2001.� [Abstract] [Full
text] [PDF]
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Kerppola, TK:�
Protein-DNA interactions: structure and energetics.� Encyclopedia of Life Sciences, Macmillan
Reference Ltd., 2001.� [Home page]
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Kerppola, TK:�
Molecular architecture and dynamics of transcription-regulatory protein
complexes. HHMI Research in Progress, 2001.�
[Full
text]
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Leonard, DA and Kerppola, TK: DNA bending determines
Fos-Jun heterodimer orientation. Nature Structural Biology, 5:877-881,
1998.� [Abstract] [Full
text] [PDF]
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Kerppola, TK: Transcriptional cooperativity: bending
over backwards and doing the flip. Structure, 6:549-554, 1998.� [Abstract] [Full
text] [PDF]
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Diebold, RJ, Rajaram, N, Leonard, D.A and Kerppola, TK:
Molecular basis of cooperative DNA bending and oriented heterodimer binding in
the NFAT1-Fos-Jun-ARRE2 complex. Proc. Natl. Acad. Sci. U.S.A., 95:7915-7920,
1998.� [Abstract] [Full
text] [PDF]
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Kerppola, TK: Molecular architecture of transcription
factor complexes.� HHMI Research in
Progress, p. 339-340, 1997-1998.� [Full
text]
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Rajaram, N and Kerppola, TK: DNA bending by Fos-Jun and
the orientation of heterodimer binding depend on sequence of the AP-1 site.
EMBO J, 16:2917-2926, 1997.� [Abstract] [Full Text] [PDF]
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Kerppola, TK and Curran, T: The transcription
activation domains of Fos and Jun induce DNA bending through electrostatic
interactions. EMBO J, 16:2907-2916, 1997.�
[Abstract]
[Full Text] [PDF]
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Leonard, D, Rajaram, N and Kerppola, TK: Structural
basis of DNA bending and oriented heterodimer binding by Fos and Jun. Proc.
Natl. Acad. Sci. U.S.A., 94:4913-4918, 1997. �
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Kerppola, TK: Comparison of DNA bending by Fos-Jun and
phased A tracts by multifactorial phasing analysis.� Biochemistry, 36:10872-10884, 1997.� [Abstract]
[Full
Text] [PDF]
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Kerppola, TK: Molecular architecture of transcription
factor complexes. HHMI Biennial Scientific Report, p. 76-77, 1996-1998.
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Penix, LA, Sweetser, MT, Weaver, WM, Hoeffler, JP,
Kerppola, TK and Wilson, CB: The proximal regulatory element of the
interferon-promoter mediates selective expression in T cells. J. Biol. Chem.
271:31964-31972, 1996.� [Abstract] [Full Text] [PDF]
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Ito, K, Asano, M, Hughes, P, Kohzaki, H, Masutani, C,
Hanaoka, F, Kerppola, TK, Curran, T, Murakami, Y and Ito, Y: c-Jun stimulates
origin-dependent DNA unwinding by polyomavirus large T antigen.� EMBO J, 15:5636-5646, 1996.� [Abstract]
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Kerppola, TK: Fos and Jun bend the AP-1 site: Effects
of probe geometry on the detection of protein induced DNA bending. Proc. Natl.
Acad. Sci. U.S.A., 93: 10117-10122, 1996.�
[Abstract]
[PDF]
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Kerppola, TK and Curran, T:� Zen and the art of Fos and Jun.� Nature, 373: 199-200, 1995.
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Robertson, LM, Kerppola, TK, Vendrell, M, Luk, D,
Smeyne, RJ, Bocchiaro, C, Morgan, JI and Curran, T:� Regulation of c-fos expression in transgenic mice requires
multiple interdependent control elements.�
Neuron, 14: 241-252, 1995.� [Abstract]�
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Kerppola, TK and Curran, T:� A conserved region adjacent to the domain is required for
recognition of an extended DNA binding site by Maf/Nrl family proteins.� Oncogene, 9 (11): 3149-3158, 1994.�
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Yaseen, NR, Park, J, Kerppola, TK, Curran, T and
Sharma, S:� A central role for Fos in
human B and T cell NFAT (Nuclear Factor of Activated T Cells):� an Acidic Region is Required for In Vitro
Assembly.� Molecular and Cellular
Biology, 14 (10): 6886-6895, 1994.� [Abstract]
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Patel, LR, Curran, T and Kerppola, TK:� Energy transfer analysis of Fos-Jun
dimerization and DNA binding.� Proc.
Natl. Acad. Sci. USA, 91 (14): 7360-7364, 1994.� [Abstract]
[PDF]
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Kerppola, TK and Curran, T:� Maf and Nrl can bind to AP-1 sites and form
heterodimers with Fos and Jun.�
Oncogene, 9 (3): 675-684, 1994.
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Hsu, W, Kerppola, TK, Chen, P-L, Curran, T and
Chen-Kiang, S:� Fos and Jun repress
transcription activation by NF-IL6 through association at the basic zipper
region.�� Molecular and Cell Biology, 14
(1): 268-276, 1994.� [Abstract]
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McCaffrey, PG, Luo, C, Kerppola, TK, Jain, J,
Badalian, T, Ho, A, Burgeon, E, Lane, WS, Lambert, JN, Curran, T, Verdine,
GL,� Rao, A and Hogan, PG: :� Isolation of the cyclosporin-sensitive T
cell transcription factor NFATp.�
Science, 262: 750-754, 1993.
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Jain, J, McCaffrey, PG, Miner, Z, Kerppola, TK,
Lambert, JN, Verdine, GL, Curran, T and Rao, A:� The T cell transcription factor NFATp is a substrate for
calcineurin and interacts with the DNA-binding domains of Fos and Jun.� Nature, 365 (6444): 352-355, 1993.
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Kerppola, TK and Curran, T:� Selective DNA bending by a variety of bZIP proteins.� Molecular and Cell Biology, 13 (9):
5479-5489, 1993.� [Abstract]
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Kerppola, TK, Luk, D and Curran, T:� Fos is a preferred target for glucocorticoid
receptor inhibition of AP1 activity in vitro.�
Molecular and Cell Biology 13 (6): 3782-3791, 1993.� [Abstract]
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Baker, SJ, Kerppola, TK, Luk, D, Vandenberg, MT,
Marshak, DR, Curran, T and Abate, C:�
Jun is phosphorylated by several protein kinases at the same sites
modified in serum stimulated fibroblasts.�
Molecular and Cell Biology, 12 (10): 4694-4705, 1992. �[Abstract]
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Kerppola, TK and Curran, T:� DNA bending by Fos and Jun:� The flexible hinge model.� Science, 254: 1210-1214, 1991.
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Kerppola, TK and Curran, T:� Fos�Jun heterodimers and Jun homodimers bend DNA in opposite
orientations:� Implications for
transcription factor cooperativity. Cell, 66: 317-326, 1991.� [Abstract]�
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Kerppola, TK and Curran, T:� Transcription factor interactions: Basics on zippers.� Current Opinion in Structural Biology,� 1: 71-79, 1991.