We are interested in animal behavior and neuronal physiology and we focus on using novel technologies and nano-tools in order to investigate intracellular mechanisms. The dynamics of intracellular systems is in the core of this research and we combine biochemistry and molecular biology methods with engineering techniques and computational and modeling tools.
Complex Bio-Nano-Dynamics of Axonal Transport We are studying kinesin-mediated axonal transport. We combine cell biology techniques, microfluidics and modeling to study obstructions and delays in motor protein motion. We aim to connect our findings with observations from neurodegenerative diseases.
Part
of a microfluidic device used to culture neurons
Non-Linear
Dynamics in Artificial Neuronal CircuitsThis project focuses on modeling
artificial neuronal networks and investigate the parameters which
affect their performance and connectivity. Using cultured neurons,
we are also running experiments to establish a cross talk between
the two approaches.
Changes
in a neuronal network activity by altering maximum conductance
and rise time
(generated by Ehsan Mizrakhalili) Magnetic Field Effects on Model Organisms Locomotion Control and Mechanics Our research includes experiments with the C. elegans
nematode exposed to magnetic field, after being fed with magnetic
nanoparticles. We also model the interaction between magnetic
field and ingested particles. We are interested in both the
magnetic and the mechanical forces affecting intracellular
structures and overall animal behavior.
Paramagnetic
nanoparticles inside worms. Left: Scanning electron microscopy,
Right: confocal microscopy
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University of Michigan |