Oxidative Arylation: Spongebob Edition

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Maoecrystal V has displayed potent and selective inhibitory activity against HeLa cells. Its structure is also quite fascinating given its pentacyclic framework ring and its six stereocenters. We will examine one step of the synthesis of Maoecrystal V involving the conversion of Molecule 8 to Molecule 10. This conversion is done through a process called oxidative arylation, which you will be able to learn more in depth about by examining the contents of this website.

 

Gong, J.; Lin, G.; Sun, W.; Li, C.; Yang, Z. J. Am. Chem. Soc. 2010, 132, 16745–16746.

 

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