Leading Question
Speculate as to why CrO3-3,5-dimethylpyrazole complex was used in this transformation. Are there any other methods to achieve the same transformation?
CrO3-DMP is a well-known allylic oxidizing reagent, providing conjugate enones 2-11 and sometimes, in minor amounts, epoxides. This is supported by the paper by G. Aranda. It is used in the situation of our reaction to create an enone. We could have used the “greener” bleach method described in class to get the same result, as well as using PCC or Jones Reagent. |