luigi 2

 

EXPERIMENTAL PROCEDURE

 

A solution of dimethyl-1-diazo-2-oxopropylphosphonate and the aldehyde 12 in methanol is created and the potassium carbonate is added at 0°C under argon atmosphere. The mixture is stirred for 2.5 hours. Aqueous saturated ammonium chloride and pentane were then added. The organic layer was separated, dried with sodium sulfate, and evaporated. An 88% yield of acetylene 13 was collected using column chromatography on silica gel.

Liquid-Liquid Extraction: a method for separating organic and inorganic liquids from each other in which the liquid misture is added to a separatory funnel. The denser of the two products will sink to the bottom. Three flasks are used to collect the layers: one to collect the bottom layer, one to collect the transition between layers, and one to collect the top layer. The organic layer can be identified based on its density and the density of the other materials.
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