Selected Peer Reviewed Journal Articles


Zhao Y., Liu L., Sun W., Lu J., McEachern D, Li X., Yu S., Denzil B., Ochsenbein P., Ferey V., Carry J.C., Deschamps J. R., Sun D., and Shaomeng Wang, Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 inhibitors.,  Journal of the American Chemical Society, 2013; 135(19):7223-7234.full text in PDF


Hacer Karatas, Elizabeth C Townsend, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou, and Shaomeng Wang, High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction,  Journal of the American Chemical Society, 2013; 135(2):669-682. full text in PDF


Chen  J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl-2 and Bcl-xL Capable of Achieving Complete Tumor Regression. J Med Chem. 2012;55(19); 8502-8514. full text in PDF



Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S. LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling. Cancer Res. 2012, 72, 1229-1238.full text in PDF


Yang CY, Sun H, Chen J, Nikolovska-Coleska Z, Wang S. Importance of ligand reorganization free energy in protein-ligand binding-affinity prediction. J Am Chem Soc. 2009, 131(38):13709-13721. full text in PDF


J. Lu, L. Bai, H. Sun, Z. Nikolovska-Coleska, D. McEachern, S. Qiu, R. S. Miller, H. Yi, S. Shangary, Y. Sun, J. L. Meagher, J. A. Stuckey, S. Wang, SM-164: A novel, bivalent Smac mimetic induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Research 2008, 68, 9384-93. full text in PDF


Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang, S.; Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A. 2008, 105, (10), 3933-3938. full text in PDF


Haiying Sun.; Zaneta Nikolovska-Coleska.; Jianfeng Lu.; Jennifer L. Meagher.; Chao-Yie Yang.; Su Qiu.; York Tomita.; Yumi Ueda.; Sheng Jiang.; Krzysztof Krajewski.; Peter P. Roller.; Jeanne A. Stuckey.;Wang, S. Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP J. Am. Chem. Soc 2007, 129, (49),15279-15294. full text in PDF


Ding, K.; Lu, Y.; Nikolovska-Coleska, Z.; Qiu, S.; Ding, Y. S.; Gao, W.; Stuckey, J.; Krajewski, K.; Roller, P. P.; Tomita, Y.; Parrish, D. A.; Deschamps, J. R.; Wang, S., Structure-based design of potent non-peptide MDM2 inhibitors. Journal of the American Chemical Society 2005, 127, (29), 10130-10131. full text in PDF


Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, York Tomita, Peter Roller and Shaomeng Wang, Structure-based design of potent, conformationally constrained Smac mimetics, J Am Chem Soc 2004; 126(51):16686-16687. full text in PDF



Last updated on December 4, 2013 by Chao-Yie Yang