Publications
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68
"Collisional and Coulombic Unfolding of Gas-Phase Proteins: High Correlation to Their Domain Structures in Solution." Yueyang Zhong, Linjie Han, Brandon T. Ruotolo
Angew. Chem. Int. Ed. (2014), doi: 10.1002/anie.201403784
Link67"Integrative modelling coupled with ion mobility mass spectrometry reveals structural features of the clamp loader in complex with single-stranded DNA binding protein." Argyris Politis, Ah Young Park, Zoe Hall, Brandon T. Ruotolo, Carol V. Robinson.
J Mol Biol. (2013), doi: 10.1016/j.jmb.2013.04.006.
Link66"Robotically assisted titration coupled to ion mobility-mass spectrometry reveals the interface structures and analysis parameters critical for multiprotein topology mapping" Yueyang Zhong, Jun Feng, Brandon T. Ruotolo.
Anal Chem. (2013), doi: 85(23):11360-8
Link65"Ion mobility-mass spectrometry of intact protein-ligand complexes for pharmaceutical drug discovery and development" Shuai Niu, Jessica N. Rabuck, Brandon T. Ruotolo.
Current Opinion in Chemical Biology (2013), doi:10.1016/j.cbpa.2013.06.019
Link64"An Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry." Jessica N. Rabuck, Suk-Joon Hyung, Kristin S. Ko, Christel C. Fox, Matthew B. Soellner, Brandon T. Ruotolo.
Anal. Chem. (2013), doi:10.1021/ac4012655
Link63"Hofmeister Salts Recover a Misfolded Multiprotein Complex for Subsequent Structural Measurements in the Gas Phase" Linjie Han, Brandon T. Ruotolo.
Angew. Chem. Int. Ed. (2013), doi: 10.1002/anie.201301893
Link62"Analysis of a Soluble (UreD:UreF:UreG)2 Accessory Protein Complex and Its Interactions with Klebsiella aerogenes Urease by Mass Spectrometry" Mark A. Farrugia, Linjie Han, Yueyang Zhong, Jodi L. Boer, Brandon T. Ruotolo, Robert P. Hausinger.
Journal of The American Society for Mass Spectrometry (2013), doi:10.1007/s13361-013-0677-y
Link61"Amyloid-b-neuropeptide interactions assessed by ion mobility-mass spectrometry" Molly T. Soper, Alaina S. DeToma, Suk-Joon Hyung, Mi Hee Lim, Brandon T. Ruotolo.
Phys. Chem. Chem. Phys.(2013), doi: 10.1039/C3CP50721A
Link60"Traveling-wave ion mobility-mass spectrometry reveals additional mechanistic details in the stabilization of protein complex ions through tuned salt additives" Linjie Han, Brandon T. Ruotolo.
International Journal for Ion Mobility Spectrometry. (2013), doi: 10.1007/s12127-013-0121-9
Link59"Resolution of Oligomeric Species during the Aggregation of Ab1-40 Using 19F NMR." Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, E Neil G. Marsh.
Biochemistry (2013), doi:10.1021/bi400027y
Link58"Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-beta species" Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Jung-Suk Choi, Ayyalusamy Ramamoorthy, Brandon T. Ruotolo, and Mi Hee Lim.
Proc. Natl. Acad. Sci. (2013), doi: 10.1073/pnas.1220326110
Link57"Dramatically stabilizing multiprotein complex structure in the absence of bulk water using tuned Hofmeister salts" Linjie Han, Suk-Joon Hyung, Brandon T. Ruotolo.
Faraday Discuss. (2013)160, 371-388
Link56"Bound cations significantly stabilize the structure of multiprotein complexes in the gas phase" Linjie Han, Suk-Joon Hyung, Brandon T. Ruotolo.
Angew. Chem. Int. Ed. (2012)51, 5692-5695.
Link55"Investigation of Flavonoid Compounds as Modulators for Metal-Associated Amyloid-b Species" Xiaoming He, Hyun Min Park, Suk-Joon Hyung, Alaina S. DeToma, Cheal Kim, Brandon T. Ruotolo, Mi Hee Lim Dalton Trans. (2012) 41, 6558-6566.
Link54"Reactivity of Diphenylpropynone Derivatives Toward Metal-Associated Amyloid-b Species" Amit S. Pithadia, Akiko Kochi, Molly T. Soper, Michael W. Beck, Yuzhong Liu, Sanghyun Lee, Alaina S. Detoma, Brandon T. Ruotolo, Mi Hee Lim.
Inorg. Chem. (2012)51, 12959-12967
Link53"Integrating mass spectrometry of intact protein complexes into structural proteomics" Suk-Joon Hyung, Brandon T. Ruotolo.
Proteomics. (2012)12, 1547-64
Link52"Ion mobility-mass spectrometry for structural proteomics" Yueyang Zhong, Suk-Joon Hyung, Brandon T. Ruotolo.
Expert Rev. Proteomics (2012)9, 47-58
Link51"Gas-Phase Protein Assemblies: Unfolding Landscapes and Preserving Native-Like Structures using Noncovalent Adducts" Joanna Freeke, Matthew F Bush, Carol V Robinson*, Brandon T. Ruotolo* (joint corresponding authors)
Chem. Phys. Lett.(2012)524, 1-9
Link50"Mass spectrometry: come of age for structural and dynamical biology" Justin LP Benesch, Brandon T Ruotolo.
Curr Opin Struct Biol. (2011)21, 641-9
Link49"Ion Mobility-Mass Spectrometry Reveals Conformational Changes in Charge Reduced Multiprotein Complexes" Russell E. Bornschein, Suk-Joon Hyung and Brandon T. Ruotolo
J. Am. Soc. Mass. Spectrom. (2011)22, 1690-8
Link48"Bound Anions Differentially Stabilize Multiprotein Complexes in the Absence of Bulk Solvent" Linjie Han, Suk-Joon Hyung, Jonathan J. S. Mayers, Brandon T. Ruotolo.
J. Am. Chem. Soc. (2011)133,11358-67
Link47"A Two-Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc " Samer Salamekh, Jeffrey R. Brender, Suk-Joon Hyung, Ravi Prakash Reddy Nanga, Subramanian Vivekanandan, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy.
J. Mol. Biol. (2011)410,294-306
Link46"Tandem Differential Mobility Analysis-Mass Spectrometry Reveals Partial Gas-Phase Collapse of the GroEL Complex." Christopher J. Hogan Jr, Brandon T. Ruotolo, Carol V. Robinson, Fernandez de la Mora J
J. Phys. Chem. B (2011)115, 3614-21
Link45"Characterizing the resolution and accuracy of a second-generation traveling-wave ion mobility separator for biomolecular ions." Yueyang Zhong, Suk-Joon Hyung, Brandon T. ; Ruotolo
Analyst (2011)136, 3534-41
Link44"Ion mobility-mass spectrometry reveals the influence of subunit packing and charge on the dissociation of multiprotein complexes." Elisabetta Boeri Erba, Brandon T. Ruotolo, Daniel Barsky, Carol V. Robinson
Anal. Chem. (2010) 82, 9702-10.
Link43"Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology." Matthew F. Bush, Zoe Hall, Kevin Giles, John Hoyes, Carol V. Robinson, Brandon T. Ruotolo
Anal. Chem. (2010) 82, 9557-65.
Link42"Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes." Argyris Politis, Ah Young Park, Suk-Joon Hyung, Daniel Barsky, Brandon T. Ruotolo, Carol V. Robinson
PLoS One (2010) 10, e12080.
Link41"Alternate dissociation pathways identified in charge-reduced protein complex ions." Kevin Pagel, Suk-Joon Hyung, Brandon T. Ruotolo, Carol V. Robinson
Anal. Chem. (2010) 18, 5363-72.
Link40A Single Subunit Directs the Assembly of the E. coli DNA Sliding Clamp Loader Ah Young Park, Slobodan Jergic, Argyris Politis, Brandon T. Ruotolo, Daniel Hirshberg, Linda L. Jessop, Jennifer L. Beck, Daniel Barsky, Mike ODonnell, Nichlas E. Dixon, Carol V. Robinson
Structure (2010) 18, 285-292.
Link39Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy Justin L.P. Benesch, Brandon T. Ruotolo, Douglas A. Simmons, Nelson P. Barrera, Nina Morgner, Luchun Wang, Helen R. Sabil, Carol V. Robinson
J. Struct. Biol. (2010)
Link38Methodology for Measuring Conformation of Solvent-disrupted Protein Subunits using T-wave Ion Mobility MS: An investigation into Eukaryotic Initiation Factors Julie A. Leary, Matthew R. Schenauer, Raluca Stefanescu, Armann Andaya, Brandon T. Ruotolo, Carol V. Robinson, Kostos Thallasinos, James Scrivens, Masaaki Sokabe, John F. Hershey
J. Am. Soc. Mass Spectrom. (2009) 20, 1699-1706.
Link37Subunit Architecture of Multi-protein Assemblies Determined using Restraints from Gas-phase Measurements Tara L. Pukala, Brandon T. Ruotolo, Min Zhou, Argyris K. Politis, Raluca Stefanescu, Julie A. Leary, Carol V. Robinson
Structure (2009) 17, 1235-1243.
Link36Residual counter ions can stabilise a large protein complex in the gas phase Joanna Freeke, Carol V. Robinson, Brandon T. Ruotolo
Int. J. Mass Spectrom. (2010), 298, 91-98
Link35A Monte Carlo Approach for Assessing the Specificity of Protein Oligomers Observed in Nano-electrospray Mass Spectra Laura A. Lane, Brandon T. Ruotolo, Carol V. Robinson, Giorgio Favrin, Justin L. P. Benesch
Int. J. Mass Spectrom. (2009), 283, 169-177.
Link34Gas-phase Unfolding and Disassembly Reveals Stability Differences in Ligand-bound Multi-protein Complexes Suk-Joon Hyung, Carol V. Robinson, Brandon T. Ruotolo
Chem. Biol. (2009), 16, 382-390.
Link33Coupling Microdroplet Microreactors with Mass Spectrometry: Reading the Contents of Single Droplets On-line Luis M. Fidalgo, Graeme Whyte, Brandon T. Ruotolo, Justin L. P. Benesch, Florian Stengel, Chris Abell, Carol V. Robinson, Wilhelm T.S. Huck
Agnew. Chem. Int. Ed. (2009), 48, 3665-3668.
Link32Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease Summer L. Bernstein, Nichlas F. Dupuis, Noel Lazo, Thomas Wyttenbach, Margaret M. Condron, Gal Bitan, David B. Teplow, Joan-Emma Shea, Brandon T. Ruotolo, Carol V. Robinson, Michael T. Bowers
Nature Chem. (2009), 1, 326-331.
Link31Quadrupole Time-of-Flight Mass Spectrometer Modified for Higher-Energy Dissociation Reduces Protein Assemblies to Peptide Fragments Justin L. P. Benesch, Brandon T. Ruotolo, Frank Sobott, Jason Wildgoose, Anthony Gilbert, Robert H. Bateman, Carol V. Robinson
Anal. Chem. (2009), 81, 1270-1274
Link30Ion Mobility-Mass Spectrometry Analysis of Large Protein-Protein Complexes Brandon T. Ruotolo, Justin L. P. Benesch, Alan M. Sandercock, Suk-Joon Hyung, Carol V. Robinson
Nature Prot. (2008), 3, 139-1152.
Link29Subunit architecture of intact protein complexes from mass spectrometry and homology modeling Thomas Taverner, Helena Hernández, Michal Sharon, Brandon T. Ruotolo, Damien Davos, Robert Russell, Carol V. Robinson
Acc. Chem. Res. (2008), 41, 617-627.
Link28Ion Mobility-Mass Spectrometry Reveals Long-lived, Unfolded Intermediates in the Dissociation of Protein Complexes Brandon T. Ruotolo, Suk-Joon Hyung, Paula M. Robinson, Kevin Giles, Robert H. Bateman, Carol V. Robinson
Agnew. Chem. Int. Ed. (2007) 46, 8001-8004.
Link27Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics Justin L. P. Benesch, Brandon T. Ruotolo, Douglas A. Simmons, Carol V. Robinson
Chem. Rev. (2007) 107, 3544-3567.
Link26Aspects of Native Protein Structure are Retained in Vacuum Brandon T. Ruotolo and Carol V. Robinson
Curr. Opin. Chem. Biol. (2006) 10, 402-408.
Link25Structural Basis for the Inhibition of Activin Signaling by Follistatin Adrian E. Harrington, Samantha Morris-Triggs, Brandon T. Ruotolo, Carol V. Robinson, Shin-ichi Ohnuma, Marko Hyvönen
EMBO J. (2006) 25, 1035-1045.
Link24"Accurate Mass Measurements Defines the Protein Composition of Intact Ribosomes and 30S Ribosomal subunits Adam R. McKay, Brandon T. Ruotolo, Carol V. Robinson
J. Am. Chem. Soc. (2006) 128, 11433-11442.
Link23Tandem Mass Spectrometry Reveals the Quaternary Organization Of Macromolecular Assemblies Justin L.P. Benesch, J. Andrew Aquilina, Brandon T. Ruotolo, Frank Sobott, Carol V. Robinson
Chem. Biol. (2006) 13, 597-605.
Link22"Evidence for Macromolecular Protein Rings in the Absence of Bulk Water Brandon T. Ruotolo, Kevin Giles, Iain Campuzano, Alan M. Sandercock, Robert H. Bateman, Carol V. Robinson
Science (2005) 310, 1658-1661.
Link21Characterization of Symmetrical Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75. Jukka P. Aurikko, Brandon T. Ruotolo, J. G. Grossmann, M. Moncrieffe, Elaine Stephens, V-M. Leppanen, Carol V. Robinson, M. Saarma, R. A. Bradshaw, Tom L. Blundell
J. Biol. Chem. (2005) 280, 33453-33460.
Link20The Structure of Gas-Phase Bradykinin Fragment 1-5 (RPPGF) Ions: An Ion Mobility Spectrometry and H/D Exchange Ion-Molecule Reaction Chemistry Study Holly A. Sawyer, Joseph T. Marini, Earle G. Stone, Brandon T. Ruotolo, Kent J. Gillig, David H. Russell
J. Am. Soc. Mass Spectrom. (2005) 16, 893-905.
Link19Ion Mobility-Mass Spectrometry: A New Paradigm for Proteomics John A. McLean, Brandon T. Ruotolo, Kent J. Gillig, David H. Russell Int.
J. Mass Spectrom. (2005) 240, 301-315.
Link18The Influence and Utility of Varying Field Strength for the Separation of Tryptic Peptides by Ion Mobility-Mass Spectrometry Brandon T. Ruotolo, John A. McLean, Kent J. Gillig, David H. Russell
J. Am. Soc. Mass Spectrom. (2005) 16, 158-165.
Link17Analysis of Phosphorylated Peptides by Ion Mobility-Mass Spectrometry Brandon T. Ruotolo, Kent J. Gillig, Amina S. Woods, Thomas F. Egan, Michael V. Ugerov, J. Albert Schultz, David H. Russell
Anal. Chem. (2004) 76, 6727-6733.
Link16Ion Mobility-Mass Spectrometry Applied to Cyclic Peptide Analysis: Conformational Preferences of Gramicidin S and Linear Analogues in the Gas Phase Brandon T. Ruotolo, Colby C. Tate, David H. Russell
J. Am. Soc. Mass Spectrom. (2004) 15, 870-878.
Link15Gas-Phase Conformations of Proteolytically-Derived Protein Fragments: The Influence of Solvent on Peptide Conformation Brandon T. Ruotolo and David H. Russell
J. Phys. Chem. B. (2004) 108, 15321-15331.
Link14Resolution Equations for High-Field Ion Mobility Spectrometry Guido F. Verbeck, Brandon T. Ruotolo, Kent J. Gillig, David H. Russell
J. Am. Soc. Mass Spectrom. (2004) 15, 1320-1324.
Link13Peak Capacity of Ion Mobility Separation. Utility of Altering Drift Gas Polarizability for Tryptic Peptide Separation Brandon T. Ruotolo, John A. McLean, Kent J. Gillig, David H. Russell
J. Mass Spectrom. (2004) 39, 361-367.
Link12An Electrostatic Ion Guide for Ion Mobility-Mass Spectrometry Kent J. Gillig, Brandon T. Ruotolo, Earle G. Stone, David H. Russell
Int. J. Mass Spectrom. (2004) 239, 43-49.
Link11Peak Capacity of Ion Mobility Separation. Separation of Peptides in Helium Brandon T. Ruotolo, Kent J. Gillig, Earle G. Stone, David H. Russell
J. Chrom. B. (2002) 782, 385-392.
Link10A Fundamental Introduction to Ion Mobility Mass Spectrometry Applied to the Analysis of Biomolecules Guido F. Verbeck, Brandon T. Ruotolo, Holly A. Sawyer, Kent J. Gillig, David H. Russell
J. Biomolecular Tech. (2002) 13(2), 56-61.
Link9Oligonucleotide analysis with MALDI-ion-mobility-TOFMS John M. Koomen, Brandon T. Ruotolo, Kent J. Gillig, John A. McLean, David H. Russell, Mijeong Kang, Kim R. Dunbar, Katrin Fuhrer, Marc Gonin, J. Albert Schultz.
Anal. Bioanal. Chem. (2002), 373(7), 612-617.
Link8Distinguishing between Phosphorylated and Non-phosphorylated Peptides by Ion Mobility-Mass Spectrometry Brandon T. Ruotolo, Guido F. Verbeck IV, Lisa M. Thompson, Amina S. Woods, Kent J. Gillig, David H. Russell J. Proteome Res. (2002), 1(4), 303-306.
Link7Observation of Conserved Solution-Phase Secondary Structure in Gas-Phase Tryptic Peptides Brandon T. Ruotolo, Guido F. Verbeck IV, Lisa M. Thompson, Kent J. Gillig, David H. Russell
J. Am. Chem. Soc. (2002) 124(16), 4214-4215.
Link6A Study of Peptide-Peptide Interactions Using MALDI Ion Mobility o-TOF and ESI Mass Spectrometry Amina S. Woods, John M. Koomen, Brandon T. Ruotolo, Kent J. Gillig, David H. Russell, Katrin Fuhrer, Marc Gonin, Thomas F. Egan, and Albert J. Schultz
J. Am. Soc. Mass Spectrom. (2002) 13(2), 166-169.
Link5Analysis of Protein Mixtures by MALDI-Ion Mobility-Orthogonal Time-of-Flight Mass Spectrometry Brandon T. Ruotolo, Kent J. Gillig, Earle G. Stone, David H. Russell, Katrin Fuhrer, Marc Gonin, and Albert J. Schultz
Int. J. Mass Specrtrom. (2002), 219 (1), 253-267.
Link4Optimization of a MALDI-IM-SID-o-TOF Mass Spectrometer: Simultaneous Acquisition of Drift Time-Resolved MS1 and MS2 Spectra Earle G. Stone, Kent J. Gillig, Brandon T. Ruotolo, David H. Russell
Int. J. Mass Specrtrom. (2001) 212 (1-3), 519-533.
Link3MALDI-Ion Mobility-Surface Induced Dissociation-Time-of-Flight mass spectral analysis of "in solution" digested proteins Earle G. Stone, Kent J. Gillig, Brandon T. Ruotolo, Katrin Fuhrer, Marc Gonin, Albert J. Schultz, and David H. Russell
Anal. Chem. (2001) 73 (10), 2233-2238.
Link2Coupling High-Pressure MALDI with Ion Mobility-Orthogonal Time-of-Flight Mass Spectrometry Kent J. Gillig, Brandon T. Ruotolo, Earle G. Stone, and David H. Russell, Katrin Fuhrer, Marc Gonin, and Albert J. Schultz
Anal. Chem. (2000) 72 (17), 3965-3971.
Link1"Development of a sequential injection system in the capillary format for determinations of the IpaC protein Dana M. Spence, Eric, D. Knoll, Brandon T. Ruotolo, Jens Bjerregaard
Anal. Chim. Acta (2000) 409 (1-2) 3-8.
Link