Group Members | Ruotolo Research Group

Research: Development of Ion Mobility-Mass Spectrometry as a High-throughput Approach for Structural Genomics, which includes enhanced approaches for generating structurally-informative subcomplexes from protein complexes in solution and investigating shape and flexibility information within a multi-protein complex.

Suk Hyung

Background: M.Sci. in Chemistry, Imperial College London, UK

Ph.D. in Chemistry, University of Cambridge

Currently at Genentech, South San Francisco, CA

Russ Bornschein

Background: BS in Chemistry from Denison University

Research: Development of gas-phase charge manipulation strategies for the study of charge effects in gas-phase structure, fragmentation pathways, and the study of protein-ligands binding and separation of oligomeric proteins.

Linjie Han

B.S. in Applied Chemistry, Tongji University, Shanghai, China

M.S. in Bioinorganic Chemistry, Tongji University, Shanghai, China

Ph.D. in Analytical Chemistry, University of Michigan, Ann Arbor

Currently at AbbVie, North Chicago, IL

Molly Soper

B.S. of Chemistry - Aquinas College, Grand Rapids MI
M.S. Chemistry - University of Michigan, Ann Arbor MI

My research focuses on the aggregation of proteins implicated in disease, such as Amyloid Beta and p53. Using IM-MS it is possible to characterize not only the aggregation of the proteins on their own but also their interactions with proteins, peptides and other small molecules as potential therapeutics . Funding for my work has been provided by The Proteome Informatics of Cancer Training Program (NIH Training Grant T32 CA14004)

Shuai Niu

B.S. Degree in Nankai Univ. China 2010

Shuai's research focuses on studying the Collision Induced Unfolding (CIU) of multi-protein ligand complexes and using Ion Mobility Mass Spectrometry (IM-MS) to assess small molecule binding within large protein assemblies. The ultimate goal is to use this CIU approach for high-throughput ligand screening.

Jessica Rabuck-Gibbons

B. S. Duquesne University
Advisor: Dr. Rita Mihailescu
Honors Thesis: A Study of the Fragile X Mental Retardation Protein and its Interactions with G Quadruplex RNA

Research Interests: Obtaining information for structural biology studies using ion mobility mass spectrometry

Joeseph Eschweiler

B.S. in Chemistry from University of Wisconsin-Milwaukee

Yuwei Tian

B.S. in Chemistry from Nanjing University, China

Billy Clifford-Nunn

Background: B.S. in Chemistry, University of Michigan - Flint

M.S. in Chemistry, University of Michigan M.S. in Secondary Science Education, University of Michigan

Ph.D in Chemistry, University of Michigan

Current: Assistant Professor at Fitchburg State University, Fitchburg, MA

Richard Kerr

BSc (Hons.) Biochemistry: University of Sussex (United Kingdom), 2009
Final year project: Production of a novel protein encoding multiple consensus tetratricopeptide repeats.
Supervisor: Dr Ewan Main.

PhD Chemistry: University College London (United Kingdom), 2013
Title: Ion Mobility & Mass Spectrometric Studies of Macromolecules Required for Organism Viability
Supervisor: Dr Konstantinos Thalassinos.

Richard’s core research focus within the Ruotolo lab is the development of high throughput screening techniques for the analysis of potential amyloid beta inhibitors, using ion mobility mass spectrometry methods. He is funded by the newly founded University of Michigan protein folding disease initiative.