We are developing new immunotherapies and vaccines by applying the basic principles of pharmaceutics and biomedical engineering.
Engineering Immunity with Synthetic materials
We are developing new materials that can interact with immune cells and modulate innate and adaptive immune responses. We seek to investigate cellular interaction between biomaterials and the immunological system and identify materials design criteria that dictate the outcome and ultimately immune functions. We expect that our research will lead to new technologies that can selectively target immune cells and elicit therapeutic immune responses.
Improving Cancer Immunotherapy
Our immune system can detect and eliminate foreign pathogens by generating systemic immune responses. If we can harness this tremendous potential of our own immune system and engineer cancer immunotherapy that can sense and eradicate tumors, this new strategy will bring transformative changes to cancer therapy. We are developing novel drug delivery systems that can deliver payload to immune and tumor cells, in order to enhance effector functions of immune cells against cancer. We seek to use this strategy to educate the adaptive immune system and selectively kill and eliminate primary and metastatic tumors.
Developing vaccines against Infectious Pathogens
Infectious pathogens primarily enters the host and initiate infection through mucosal tissues. However, there is currently no approved mucosal adjuvant that can achieve concerted cellular and humoral immune responses. We are addressing this major global challenge by develoing “virion-mimicdking” materials may serve as a potent mucosal vaccine platform to generate T lymphocyte and broadly-neutralizing antibody responses against various infectious pathogens.