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About Us

Our group's research interests lie at the nexus of engineering, biology and medicine. Specifically, we integrate micro/nanoengineering, single-cell technologies, and systems and synthetic biology methods with new discoveries of mechanobiology, epigenetics, and stem cell biology for advancing understanding of human development and diseases. In our research, we have made significant contributions to these areas: stem cell bioengineering, developmental bioengineering, mechanobiology, and BioMEMS. (for details, please read our Research; also see Nature News 2019, Nature News Feature 2021, MIT Technology Review 2017, MIT Technology Review 2019 highlighting our research)

Group Members

Meet the lab. Front row (from left to right): Sajedeh Nasr Esfahani, Agnes M. Resto Irizarry, Zhaoyi Xu, Shiyu Sun. Back row (from left to right): Robin Yan, Rami Tshuva, Yue Liu, Xufeng Xue, Yi Zheng, Jeyoon Bok, Jianping Fu, Aidan Terhune. (see Members)


Jianping Fu and Deborah Gumucio discuss their microfluidic platform for reliably producing stem cell colonies that mimic early stages of human development in order to investigate infertility and other big questions in maternal and child health.

Video recorded for our MCubed sponsored project, "Microfluidic systems immunology for transformative diagnostics for infants". Collaborative interdisciplinary team science to address complex clinical challenges.

Selected Publications

Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
Yi Zheng, Robin Zhexuan Yan, Shiyu Sun, Mutsumi Kobayashi, Lifeng Xiang, Ran Yang, Alexander Goedel, Yu Kang, Xuefeng Xue, Sajedeh Nasr Esfahani, Yue Liu, Agnes M. Resto Irizarry, Weisheng Wu, Yunxiu Li, Weizhi Ji, Yuyu Niu, Kenneth R. Chien, Tianqing Li, Toshihiro Shioda, and Jianping Fu
Cell Stem Cell, vol. 29, pp. 1402-1419, 2022. [PDF | Supplemental Materials]

Engineering multiscale structural orders for high-fidelity embryoids and organoids
Yue Shao, and Jianping Fu
Cell Stem Cell, vol. 29, pp. 722-743, 2022. [PDF]

Amnion signals are essential for mesoderm formation in primates
Ran Yang, Alexander Goedel, Yu Kang, Chengyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji, Fredrik Lanner, Yuyu Niu, and Kenneth Chien
Nature Communications, vol. 12, 5126, 2021. [PDF | Supplemental Materials]

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
Dennis W. Zhou, Marc A. Fernández-Yagüe, Elijah N. Holland, Andrés F. García, Nicolas S. Castro, Eric B. O’Neill, Jeroen E.G. Eyckmans, Christopher S. Chen, Jianping Fu, David D. Schlaepfer, and Andrés J. García
Nature Communications, vol. 12, 2359, 2021. [PDF | Supplemental Materials]

Spatially resolved cell polarity proteomics of a human epiblast model
Sicong Wang, Chien-Wei Lin, Chari L. Cortez, Amber E. Carleton, Craig Johnson, Linnea E. Taniguchi, Ryan F. Townshend, Venkatesha Basrur, Alexey I. Nesvizhskii, Amy W. Hudson, Blake R. Hill, Peng Zou, Jianping Fu, Deborah L. Gumucio, Mara C. Duncan, and Kenichiro Taniguchi
Science Advances, vol. 7, eabd8407, 2021. [PDF | Supplemental Materials]

First complete model of the human embryo
Yi Zheng, and Jianping Fu
Nature, vol. 591, pp. 531-532, 2021. [PDF]

Stem-cell-based embryo models for fundamental research and translation
Jianping Fu, Aryeh Warmflash, and Lutolf Matthias
Nature Materials, vol. 20, pp. 132-144, 2021. [PDF]

Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells
Jonathon M. Muncie, Nadia M.E. Ayad, Johnathon N. Lakins, Xufeng Xue, Jianping Fu, and Valerie M. Weaver
Developmental Cell, vol. 55, pp. 679-694, 2020. [PDF | Supplemental Materials]

Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche
Yuanyuan Zheng, Xufeng Xue, Agnes M. Resto Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao, and Jianping Fu
Science Advances, vol. 5, eaax5933, 2019. [PDF | Supplemental Materials]

Controlled modeling of human epiblast and amnion development using stem cells
Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu
Nature, vol. 573, pp. 421-425, 2019. [PDF]

Commentary: Debate ethics of embryo models from stem cells
Nicolas Rivron, Martin Pera, Janet Rossant, Alfonso Martinez Arias, Magdalena Zernicka-Goetz, Jianping Fu, Suzanne van den Brink, Annelien Bredenoord, Wybo Dondorp, Guido de Wert, Insoo Hyun, Megan Munsie, and Rosario Isasi
Nature, vol. 564, pp. 183-185, 2018. [PDF]

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Xufeng Xue, Yubing Sun, Agnes M. Resto-Irizarry, Ye Yuan, Koh Meng Aw Yong, Yi Zheng, Shinuo Weng, Yue Shao, Yimin Chai, Lorenz Studer, and Jianping Fu
Nature Materials, vol. 17, pp. 633-641, 2018. [PDF | Supplemental Materials]

A pluripotent stem cell-based model for post-implantation human amniotic sac development
Yue Shao, Kenichiro Taniguchi, Ryan F. Townshend, Toshio Miki, Deborah L. Gumucio, and Jianping Fu
Nature Communications, vol. 8, 208, 2017. [PDF | Supplemental Materials]

More Publications...