Absence of normal activation of the left anterior fusiform gyrus during naming in left temporal lobe epilepsy.


Henry, T.R., Buchtel, H.A., Koeppe, R.A., Pennell, P.B., Kluin, K.J. and Minoshima, S.
ABSTRACT
Left mesial temporal lobe epilepsy (TLE) patients often have impaired visual confrontation naming. We studied 10 normal and 13 left TLE subjects with 15-O-H2O PET during visual confrontation naming. Z-statistical mapping detected multiple regions of significant CBF increases within individuals. The left fusiform gyrus was activated in nine normal subjects, but only in two TLE patients (a difference significant at p<0.001). Other foci of activation were more variable in normal and epileptic subjects. Impaired naming ability may be associated with failure to increase CBF in the left fusiform gyrus in TLE
6 August 1997 (HAB)
http://www-personal.umich.edu/~gusb/epifusiform.html